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J Psychother Pract Res 8:103-114, April 1999
© 1999 American Psychiatric Association

Special Article

Some Neurobiological Aspects of Psychotherapy: A Review

Deborah Y. Liggan, M.D. and Jerald Kay, M.D.

Ever since the idea was accepted that memory is associated with alterations in synaptic strength, studies on the cellular and molecular mechanisms responsible for the plastic changes in neurons have attracted wide interest in the scientific community. This article explores the process of memory consolidation leading to persistent modifications in synaptic plasticity as a mechanism by which psychotherapy facilitates changes in the permanent storage of information acquired throughout the individual's life. The psychobiological interrelationships of affect, attachment, and memory offer a perspective regarding the etiology and treatment of clinical disturbances of affect. Analogies between brain physiology and modes of psychotherapy provide the foundation for a review of psychiatric disorders involving the inability to control fear, obsessions, compulsions, and delusions, all of which respond to psychotherapeutic interventions.(The Journal of Psychotherapy Practice and Research 1999; 8:103–114)




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